EDITORIALS & PODCASTS

New Studies Validate Old Wisdom

By Deborah Z. Altschuler

“They use combing to validate an active infestation, quantify lice and nits by
counting what the comb removes from their test subjects,
as well as confirm and compare therapeutic efficacy.”

The March 11, 2010 New England Journal of Medicine published a study comparing the use of a pesticide called malathion to the use of an oral antibiotic called ivermectin to determine the efficacy of each in treating children with head lice (pediculosis). http://content.nejm.org/cgi/content/short/362/10/896

According to this report, head lice are universal human parasites affecting over 100 million people worldwide each year. The study was conducted on children who had already been treated with topical insecticides yet continued to have live lice. “Infestation was confirmed and monitored by means of fine-toothed combing.” Adverse events for the participants included gastroenteritis, nausea, vomiting, impetigo and convulsions.

The ivermectin (antibiotic) comparison study was performed on children as young as 2 years of age. Earlier studies using malathion have been performed on children as young as 6 months of age. A list of various other new products for killing lice are being studied with future ivermectin trials scheduled for very young children.
http://clinicaltrials.gov/ct2/results?cond=%22Lice+Infestations%22

Study after study reminds us that none of the experimental treatments, or those already cleared by the FDA, are 100% effective against lice and nits (lice eggs). This is why the product label for pediculicides (pesticides) recommends retreatment in 7-10 days. It also reminds us that children are exposed to 2 applications of pediculicides with the purchase of one treatment. Therefore it is curious that the NEJM article offers “that in real life, the persistence of live lice one day after insecticide application strongly suggests resistance.” There are many variables to account for treatment failure. Resistance is just one of them. Remaining nits that hatch new lice is another.

And while we have documented evidence of lice resistance to some of the most widely used products, it is unimaginable that physicians would choose to use a heavy hand with antibiotics when safer choices are available.

Rather than take the inherent health risks of following one insecticide or chemical or prescription with another, a more rational approach would be the same method researchers rely on to account for their scientific findings. They use combing for lice and nits to validate an active infestation, quantify lice and nits by counting what the comb removes from their test subjects, as well as confirm and compare therapeutic efficacy. In fact, the development of effective combs has been a boon to clinical studies – allowing for more objective data collection. The combing method is accepted and published as an integral part of clinical trials.

Perhaps with a dose of irony, the NEJM article is another example in which combing is required for research and product development. This includes a study NPA found not only promising as an important compliment to combing, but also as a much more rational non-chemical alternative to pesticides.

As published in 2006 Pediatrics: “After using a louse comb to confirm infestation, one side of each participant’s scalp was combed thoroughly to remove all lice and eggs as a control. The child’s whole head was then treated, followed by a thorough combing of the non-control side of the head.” (Italics added for emphasis). http://pediatrics.aappublications.org/cgi/content/full/118/5/1962

Perhaps the greatest benefit to recent clinical studies is the way in which they offhandedly and consistently stress that “all lice and eggs” can be removed and accounted for with combing.

And it’s not just about live lice as the NEJM article seems to imply. Nits must also be accounted for. Infestations are established by lice laying eggs that hatch new lice. This is their cycle of life -– their basic biology.

Combing is a scientifically reliable method to remove all lice and nits – which is another way to say it can end an infestation – literally. Combing is the safest and most cost effective approach that accomplishes what chemicals cannot. It enables families to be self-reliant, proactive, and preventive. It allows for regular screening and early detection which makes the combing approach even more practical and realistic.

While chemical treatments, pediculicides, and broad spectrum antibiotics develop resistance and potentially adverse health effects, nothing compares to the kindness of a comb.

Deborah Z. Altschuler
President
National Pediculosis Association
www.headlice.org

The National Pediculosis Association (NPA) is a 501(c) 3 non-profit organization dedicated to the mission of setting the highest possible public health standards for children as it relates to the communicability and treatment of children with head lice. The NPA is comprised of volunteers including its Scientific Advisory Board. As part of its mission, the NPA developed the LiceMeister® comb and makes it available on its website www.headlice.org. All proceeds from the comb allow the NPA to maintain independence from product manufacturers and stay loyal to its mission to protect children from the misuse and abuse of pesticides for lice.

ACTIVISTS IN PUBLIC HEALTH

By Deborah Z. Altschuler

"With the exception of an occasional accolade for all the hard work that goes into being an activist, I generally find myself resenting the term."

To paraphrase an old proverb, Citizen Activists will never disappoint you if you observe two rules: 1. Find out what they are; 2. Expect them to be just that. Many of us come naturally to advocacy in our role as parents. The activist in public health, however, can face a peculiar set of problems.

Regarding Pediculosis, the consensus among contemporary physicians is that head lice are essentially a nuisance, leaving treatment protocols to the pharmaceutical manufacturers who market pediculicides for direct application to human skin. Although it can be a positive force, the pharmaceutical industry is not a proper guardian of children's health.

This is where the activist evolves into educator, support system and collector of personal accounts - sometimes appalling - of families and individuals who have suffered from unnecessary, unsuccessful or excessive chemical treatments. The activist must do what disinterested experts will not do: investigate the origin, nature, methods and limits of knowledge in Pediculosis and its management. The activist must also seek allies - often the school nurses, occasionally the press, and sometimes (in cases where a child has suffered grievous harm), the lawyers - when there is no mechanism in place to exchange insights, experience and research.

With the exception of an occasional accolade for all the hard work that goes into being an activist, I generally find myself resenting the term. Perhaps it is because of what other think an activist should be. Activists are do-gooders working "on the outside" - people whose commitment to their cause keeps them from pursuing a "real job". Here are some common perceptions:

• Activists have information - Academics possess knowledge
• Activists have points of view - Scientists have hypotheses
• Activists have anecdotal evidence - Researchers have reports to the literature
• Activists provide outreach - Specialists give consultations

No matter what the cause, such perceptions can alienate the activist as a key player in providing society with what it requires in the way of a unified effort to deliver the truth - on Pediculosis-related issues or on other important matters affecting the public's health.

Meanwhile, families must be enabled to make informed decisions and seek safer alternatives before using potentially harmful but readily available chemicals for lice and scabies. The age-old disease of Pediculosis isn't going away. It is the activist's particular challenge to educate the public in spite of the relative indifference to this issue on the part of the professional communities the public turns to for advice. Ultimately, the task will be accomplished when we successfully teach the "experts" what the "experts" need to be taught. That it's not about lice - it's about kids.

Deborah Z. Altschuler
President
National Pediculosis Association
www.headlice.org

The National Pediculosis Association (NPA) is a 501(c) 3 non-profit organization dedicated to the mission of setting the highest possible public health standards for children as it relates to the communicability and treatment of children with head lice. The NPA is a volunteer organization. As part of its mission, the NPA developed the LiceMeister® comb and makes it available on its website www.headlice.org. All proceeds from the comb allow the NPA to maintain independence from product manufacturers and stay loyal to its mission to protect children from the misuse and abuse of pesticides for lice.

The National Pediculosis Association,^® Inc.
A Non-Profit Organization
Serving The Public Since 1983.

The National Pediculosis Association is a non-profit, tax exempt
organization that receives no government or agency funding.
Contributions are tax-deductible under the 501c(3) status.

©1997-2011 The National Pediculosis Association®, Inc.
All images ©1997-2011 The National Pediculosis Association®, Inc.